Ustekinumab treats psoriasis by suppressing RORC and T-box but its suppression of GATA restrains its efficacy

• Główni autorzy: Lun-Fei Liu (Autor), Ji-Su Chen (Autor), Ji-Yang Shen (Autor), Ting-Ting Dou (Autor), Jiong Zhou (Autor), Sui-Qing Cai (Autor), Min Zheng (Autor)
• Format: Książka
• Wydane: Universidade de São Paulo, 2019-04-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Psoriasis is a T-cell mediated disease that involves IL-23/Th17 and IL-12/Th1 axes. Ustekinumab, a fully human monoclonal antibody targeting the p40 subunit of both IL-12 and IL-23, has proven to be efficient and safe for treating patients with psoriasis. Yet, there have been no reports with human s...