Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development

• Главные авторы: Claudia Miranda (Автор), Alejandro Ruiz-Picazo (Автор), Paula Pomares (Автор), Isabel Gonzalez-Alvarez (Автор), Marival Bermejo (Автор), Marta Gonzalez-Alvarez (Автор), Alex Avdeef (Автор), Miguel-Ángel C (Автор)
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• Опубликовано: MDPI AG, 2022-01-01T00:00:00Z.
• Предметы: article
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The main aim of this work is the biopharmaceutical characterization of a new hybrid benzodiazepine-dihydropyridine derivative, JM-20, derived with potent anti-ischemic and neuroprotective effects. In this study, the p<i>K</i>a and the pH-solubility profile were experimentally determined....