Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development

• Main Authors: Claudia Miranda (Author), Alejandro Ruiz-Picazo (Author), Paula Pomares (Author), Isabel Gonzalez-Alvarez (Author), Marival Bermejo (Author), Marta Gonzalez-Alvarez (Author), Alex Avdeef (Author), Miguel-Ángel C (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The main aim of this work is the biopharmaceutical characterization of a new hybrid benzodiazepine-dihydropyridine derivative, JM-20, derived with potent anti-ischemic and neuroprotective effects. In this study, the p<i>K</i>a and the pH-solubility profile were experimentally determined....