NPAS2 Contributes to Liver Fibrosis by Direct Transcriptional Activation of Hes1 in Hepatic Stellate Cells

• Main Authors: Tao Yang (Author), Peng Yuan (Author), Yi Yang (Author), Ning Liang (Author), Qian Wang (Author), Jing Li (Author), Rui Lu (Author), Hongxin Zhang (Author), Jiao Mu (Author), Zhaoyong Yan (Author), Hulin Chang (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recently, emerging evidence shows that dysregulation of circadian genes is closely associated with liver fibrosis. However, how dysregulation of circadian genes promotes liver fibrosis is unknown. In this study, we show that neuronal PAS domain protein 2 (NPAS2), one of the core circadian molecules...