A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence

• Main Authors: Claudio Festuccia (Author), Miriam Corrado (Author), Alessandra Rossetti (Author), Riccardo Castelli (Author), Alessio Lodola (Author), Giovanni Luca Gravina (Author), Massimiliano Tognolini (Author), Carmine Giorgio (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Eph kinases are the largest receptor tyrosine kinases (RTKs) family in humans. PC3 human prostate adenocarcinoma cells are a well-established model for studying Eph-ephrin pharmacology as they naturally express a high level of EphA2, a promising target for new cancer therapies. A pharmacological...