CAR-T cell potency: from structural elements to vector backbone components

• Main Authors: Marzieh Mazinani (Author), Fatemeh Rahbarizadeh (Author)
• פורמט: ספר
• יצא לאור: BMC, 2022-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract Chimeric antigen receptor (CAR) T cell therapy, in which a patient's own T lymphocytes are engineered to recognize and kill cancer cells, has achieved remarkable success in some hematological malignancies in preclinical and clinical trials, resulting in six FDA-approved CAR-T products...