Inhibitory Effects of Antiparkinsonian Drugs and Caspase Inhibitors in a Parkinsonian Flatworm Model

• Váldodahkkit: Yoshihisa Kitamura (Dahkki), Masatoshi Inden (Dahkki), Hisakazu Sanada (Dahkki), Kazuyuki Takata (Dahkki), Takashi Taniguchi (Dahkki), Shun Shimohama (Dahkki), Hidehumi Orii (Dahkki), Makoto Mochii (Dahkki), Kiyokazu Agata (Dahkki), Kenji Watanabe (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2003-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

It has been known that rotenone and 1-methyl-4-phenylpyridinium ion (MPP+, a metabolite of MPTP), which inhibit mitochondrial complex I, are useful tools for parkinsonian models in vertebrates such as primates and rodents. Planarian, an invertebrate flatworm, has a high potential for regeneration, a...