Inhibitory Effects of Antiparkinsonian Drugs and Caspase Inhibitors in a Parkinsonian Flatworm Model

• Main Authors: Yoshihisa Kitamura (Author), Masatoshi Inden (Author), Hisakazu Sanada (Author), Kazuyuki Takata (Author), Takashi Taniguchi (Author), Shun Shimohama (Author), Hidehumi Orii (Author), Makoto Mochii (Author), Kiyokazu Agata (Author), Kenji Watanabe (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It has been known that rotenone and 1-methyl-4-phenylpyridinium ion (MPP+, a metabolite of MPTP), which inhibit mitochondrial complex I, are useful tools for parkinsonian models in vertebrates such as primates and rodents. Planarian, an invertebrate flatworm, has a high potential for regeneration, a...