Novel saccharin analogs as promising antibacterial and anticancer agents: synthesis, DFT, POM analysis, molecular docking, molecular dynamic simulations, and cell-based assay

• Main Authors: Magda H. Abdellattif (Author), Ahmed Elkamhawy (Author), Mohamed Hagar (Author), Taibi Ben Hadda (Author), Wesam S. Shehab (Author), Wael Mansy (Author), Amany Belal (Author), M. M. H. Arief (Author), Mostafa A. Hussien (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Saccharine is a pharmacologically significant active scaffold for various biological activities, including antibacterial and anticancer activities. Herein, saccharinyl hydrazide (1) was synthesized and converted into 2-[(2Z)-2-(1,1-dioxo-1,2-dihydro-3H-1λ6,2- benzothiazole-3-ylidene) hydrazinyl] ace...