Novel saccharin analogs as promising antibacterial and anticancer agents: synthesis, DFT, POM analysis, molecular docking, molecular dynamic simulations, and cell-based assay

• मुख्य लेखकों: Magda H. Abdellattif (लेखक), Ahmed Elkamhawy (लेखक), Mohamed Hagar (लेखक), Taibi Ben Hadda (लेखक), Wesam S. Shehab (लेखक), Wael Mansy (लेखक), Amany Belal (लेखक), M. M. H. Arief (लेखक), Mostafa A. Hussien (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Saccharine is a pharmacologically significant active scaffold for various biological activities, including antibacterial and anticancer activities. Herein, saccharinyl hydrazide (1) was synthesized and converted into 2-[(2Z)-2-(1,1-dioxo-1,2-dihydro-3H-1λ6,2- benzothiazole-3-ylidene) hydrazinyl] ace...