In Silico Studies on GCP-Lys-OMe as a Potential 14-3-3σ Homodimer Stabilizer
14-3-3 sigma is a vital negative cell cycle regulator. Its expression is consistently downregulated in many types of cancer through gene promoter hypermethylation or proteasomal degradation. 14-3-3 sigma needs to form a homodimer to be functional, while dimers are less prone to degradation than mono...
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MDPI AG,
2022-10-01T00:00:00Z.
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