Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers

• Main Authors: Hawon Yoo (Author), Seul-Ki Choi (Author), Jaeok Lee (Author), So Hyeon Park (Author), You Na Park (Author), Soo-Yeon Hwang (Author), Jae-Ho Shin (Author), Younghwa Na (Author), Youngjoo Kwon (Author), Hwa Jeong Lee (Author), Yun-Sil Lee (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Relationships between heat shock protein 27 (HSP27) and cancer aggressiveness, metastasis, drug resistance, and poor patient outcomes in various cancer types including non-small cell lung cancer (NSCLC) were reported, and inhibition of HSP27 expression is suggested to be a possible strategy for canc...