Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers

• Principais autores: Hawon Yoo (Autor), Seul-Ki Choi (Autor), Jaeok Lee (Autor), So Hyeon Park (Autor), You Na Park (Autor), Soo-Yeon Hwang (Autor), Jae-Ho Shin (Autor), Younghwa Na (Autor), Youngjoo Kwon (Autor), Hwa Jeong Lee (Autor), Yun-Sil Lee (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2021-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Relationships between heat shock protein 27 (HSP27) and cancer aggressiveness, metastasis, drug resistance, and poor patient outcomes in various cancer types including non-small cell lung cancer (NSCLC) were reported, and inhibition of HSP27 expression is suggested to be a possible strategy for canc...