Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes

• Main Authors: Anna Motterle (Author), Sonia Gattesco (Author), Marie-Line Peyot (Author), Jonathan Lou S. Esguerra (Author), Ana Gomez-Ruiz (Author), D. Ross Laybutt (Author), Patrick Gilon (Author), Frédéric Burdet (Author), Mark Ibberson (Author), Lena Eliasson (Author), Marc Prentki (Author), Romano Regazzi (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involvement of microRNAs is well established, the contribution of long non-coding RNAs (lncRNAs) in the regulation of β-cell functions and in diabetes development remains poorly understood. The aim of this...