Impact of the Gram-Negative-Selective Inhibitor MAC13243 on In Vitro Simulated Gut Microbiota

• Egile Nagusiak: Frida Svanberg Frisinger (Egilea), Mattia Pirolo (Egilea), Duncan Y. K. Ng (Egilea), Xiaotian Mao (Egilea), Dennis Sandris Nielsen (Egilea), Luca Guardabassi (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

New Gram-negative-selective antimicrobials are desirable to avoid perturbations in the gut microbiota leading to antibiotic-induced dysbiosis. We investigated the impact of a prototype drug (MAC13243) interfering with the Gram-negative outer membrane protein LolA on the faecal microbiota. Faecal sus...