Development of a population pharmacokinetic model to characterize the pharmacokinetics of intrathecally administered tominersen in cerebrospinal fluid and plasma
Abstract Tominersen is an intrathecally administered antisense oligonucleotide targeting huntingtin mRNA which leads to a dose‐dependent, reversible lowering of cerebrospinal fluid (CSF) mutant huntingtin protein concentration in individuals with Huntington's disease. Nonlinear mixed‐effect pop...
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| Main Authors: | , , , , , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2023-09-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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