Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases

• Autori principali: José Javier López-Cano (Autore), Sigen A. (Autore), Vanessa Andrés-Guerrero (Autore), Hongyun Tai (Autore), Irene Bravo-Osuna (Autore), Irene Teresa Molina-Martínez (Autore), Wenxin Wang (Autore), Rocío Herrero-Vanrell (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The present study aims to develop a thermo-responsive-injectable hydrogel (HyG) based on PLGA-PEG-PLGA (PLGA = poly-(DL-lactic acid co-glycolic acid); PEG = polyethylene glycol) to deliver neuroprotective agents to the retina over time. Two PLGA-PEG PLGA copolymers with different PEG:LA:GA ratios (1...