A Small β-Carboline Derivative "B-9-3" Modulates TGF-β Signaling Pathway Causing Tumor Regression in Vivo

• Main Authors: Hui Zhong (Author), Abdelkader Daoud (Author), Jichun Han (Author), Xiaohong An (Author), Caili Qiao (Author), Lanlan Duan (Author), Yichuan Wang (Author), Zhenfeng Chen (Author), Jia Zhou (Author), Jing Shang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeting tumor microenvironment (TME) is crucial in order to overcome the anti-cancer therapy resistance. In this study, we report the antitumor activity of a newly synthesized β-carboline derivative "B-9-3." Here, this small molecule showed a promising antitumor activity in vivo along wi...