PPARδ Inhibits Hyperglycemia-Triggered Senescence of Retinal Pigment Epithelial Cells by Upregulating SIRT1

• Main Authors: Eun Ji Lee (Author), Jun Pil Won (Author), Hyuk Gyoon Lee (Author), Eunsu Kim (Author), Jinwoo Hur (Author), Won Jin Lee (Author), Jung Seok Hwang (Author), Han Geuk Seo (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Emerging evidence shows that peroxisome proliferator-activated receptor delta (PPARδ) plays a pivotal role in cellular aging. However, its function in retinal disease processes such as hyperglycemia-associated diabetic retinopathy is unclear. Here, we demonstrate that PPARδ inhibits premature senesc...