PPARδ Inhibits Hyperglycemia-Triggered Senescence of Retinal Pigment Epithelial Cells by Upregulating SIRT1

• Hauptverfasser: Eun Ji Lee (Verfasst von), Jun Pil Won (Verfasst von), Hyuk Gyoon Lee (Verfasst von), Eunsu Kim (Verfasst von), Jinwoo Hur (Verfasst von), Won Jin Lee (Verfasst von), Jung Seok Hwang (Verfasst von), Han Geuk Seo (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2022-06-01T00:00:00Z.
• Schlagworte: article
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Emerging evidence shows that peroxisome proliferator-activated receptor delta (PPARδ) plays a pivotal role in cellular aging. However, its function in retinal disease processes such as hyperglycemia-associated diabetic retinopathy is unclear. Here, we demonstrate that PPARδ inhibits premature senesc...