β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders

• Päätekijät: Jaana van Gastel (Tekijä), Jhana O. Hendrickx (Tekijä), Hanne Leysen (Tekijä), Paula Santos-Otte (Tekijä), Louis M. Luttrell (Tekijä), Bronwen Martin (Tekijä), Stuart Maudsley (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

G protein coupled receptors (GPCRs) were first characterized as signal transducers that elicit downstream effects through modulation of guanine (G) nucleotide-binding proteins. The pharmacotherapeutic exploitation of this signaling paradigm has created a drug-based field covering nearly 50% of the c...