Development of Biolayer Interferometry (BLI)-Based Double-Stranded RNA Detection Method with Application in mRNA-Based Therapeutics and Vaccines

• Main Authors: Dharia Sara Silas (Author), Bindiya Juneja (Author), Keerat Kaur (Author), Muralikrishna Narayanareddy Gari (Author), Yingjian You (Author), Youmi Moon (Author), Yizhuo Chen (Author), Srishti Arora (Author), Johanna Hansen (Author), Kathir Muthusamy (Author), Yue Fu (Author), Nisha Palackal (Author), Erica A. Pyles (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background:</b> In vitro-transcribed (IVT) mRNA has been established as a promising platform for therapeutics and vaccine development. Double-stranded RNA (dsRNA) is a major impurity of IVT mRNA and can trigger unfavored immune responses, potentially causing adverse events in patients...