Development of Biolayer Interferometry (BLI)-Based Double-Stranded RNA Detection Method with Application in mRNA-Based Therapeutics and Vaccines

• मुख्य लेखकों: Dharia Sara Silas (लेखक), Bindiya Juneja (लेखक), Keerat Kaur (लेखक), Muralikrishna Narayanareddy Gari (लेखक), Yingjian You (लेखक), Youmi Moon (लेखक), Yizhuo Chen (लेखक), Srishti Arora (लेखक), Johanna Hansen (लेखक), Kathir Muthusamy (लेखक), Yue Fu (लेखक), Nisha Palackal (लेखक), Erica A. Pyles (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2024-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

<b>Background:</b> In vitro-transcribed (IVT) mRNA has been established as a promising platform for therapeutics and vaccine development. Double-stranded RNA (dsRNA) is a major impurity of IVT mRNA and can trigger unfavored immune responses, potentially causing adverse events in patients...