A missense mutation of the gene encoding synaptic vesicle glycoprotein 2A (SV2A) confers seizure susceptibility by disrupting amygdalar synaptic GABA release

• Main Authors: Kentaro Tokudome (Author), Takahiro Okumura (Author), Ryo Terada (Author), Saki Shimizu (Author), Naofumi Kunisawa (Author), Tomoji Mashimo (Author), Tadao Serikawa (Author), Masashi Sasa (Author), Yukihiro Ohno (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Synaptic vesicle glycoprotein 2A (SV2A) is specifically expressed in the membranes of synaptic vesicles and modulates action potential-dependent neurotransmitter release. To explore the role of SV2A in the pathogenesis of epileptic disorders, we recently generated a novel rat model (Sv2aL174Q rat) c...