The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis

• Main Authors: Emanuela Talamonti (Author), Jelena Davegardh (Author), Anastasia Kalinovich (Author), Sten M.M. van Beek (Author), Nodi Dehvari (Author), Carina Halleskog (Author), Hamza M. Bokhari (Author), Dana S. Hutchinson (Author), Seungmin Ham (Author), Laura J. Humphrys (Author), Nicola C. Dijon (Author), Aikaterini Motso (Author), Anna Sandstrom (Author), Evelyn Zacharewicz (Author), Ilga Mutule (Author), Edgars Suna (Author), Jana Spura (Author), Karolina Ditrychova (Author), Leigh A. Stoddart (Author), Nicholas D. Holliday (Author), Shane C. Wright (Author), Volker M. Lauschke (Author), Soren Nielsen (Author), Camilla Scheele (Author), Elizabeth Cheesman (Author), Joris Hoeks (Author), Peter Molenaar (Author), Roger J. Summers (Author), Benjamin Pelcman (Author), Gopala K. Yakala (Author), Tore Bengtsson (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Simultaneous activation of β2- and β3-adrenoceptors (ARs) improves whole-body metabolism via beneficial effects in skeletal muscle and brown adipose tissue (BAT). Nevertheless, high-efficacy agonists simultaneously targeting these receptors whilst limiting activation of β1-ARs - and thus...