The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis

• প্রধান লেখক: Emanuela Talamonti (লেখক), Jelena Davegardh (লেখক), Anastasia Kalinovich (লেখক), Sten M.M. van Beek (লেখক), Nodi Dehvari (লেখক), Carina Halleskog (লেখক), Hamza M. Bokhari (লেখক), Dana S. Hutchinson (লেখক), Seungmin Ham (লেখক), Laura J. Humphrys (লেখক), Nicola C. Dijon (লেখক), Aikaterini Motso (লেখক), Anna Sandstrom (লেখক), Evelyn Zacharewicz (লেখক), Ilga Mutule (লেখক), Edgars Suna (লেখক), Jana Spura (লেখক), Karolina Ditrychova (লেখক), Leigh A. Stoddart (লেখক), Nicholas D. Holliday (লেখক), Shane C. Wright (লেখক), Volker M. Lauschke (লেখক), Soren Nielsen (লেখক), Camilla Scheele (লেখক), Elizabeth Cheesman (লেখক), Joris Hoeks (লেখক), Peter Molenaar (লেখক), Roger J. Summers (লেখক), Benjamin Pelcman (লেখক), Gopala K. Yakala (লেখক), Tore Bengtsson (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2024-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Objective: Simultaneous activation of β2- and β3-adrenoceptors (ARs) improves whole-body metabolism via beneficial effects in skeletal muscle and brown adipose tissue (BAT). Nevertheless, high-efficacy agonists simultaneously targeting these receptors whilst limiting activation of β1-ARs - and thus...