A novel tumor-activated ALA fusion protein for specific inhibition on the growth and invasion of breast cancer cells MDA-MB-231

• Main Authors: Xiufeng Liu (Author), Xintong Liu (Author), Suwen Sunchen (Author), Meixia Liu (Author), Chen Shen (Author), Juanjuan Wu (Author), Wanli Zhao (Author), Boyang Yu (Author), Jihua Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The aim of this research was to develop a novel ALA fusion protein for target to the malignant cells surface with high uPAR expression and locally release of the scorpion toxin AGAP in an uPA-cleavable manner. It will provide an effective approach for controlled release of the peptide tox...