Redox-sensitive lipophilic prodrugs: delivering unstable chemotherapeutant for improved cancer therapy

• Main Authors: Fu Li (Author), Zhao Huang (Author), Huitong Chen (Author), Lu Yan (Author), Jin Li (Author), Yue Su (Author), Qian Zhang (Author), Zhengye Huang (Author), Yaxin Zheng (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapeutic application of unmodified camptothecin (CPT) is severely restricted by its extremely low water solubility and the instability of active lactone ring. In this study, a redox-sensitive CPT-OA conjugate containing the disulfide bond (CPT-SS-OA) was used to deliver the lactone-stabilized CPT...