Hydrophobic Amino Acid Tryptophan Shows Promise as a Potential Absorption Enhancer for Oral Delivery of Biopharmaceuticals

• Автори: Noriyasu Kamei (Автор), Hideyuki Tamiwa (Автор), Mari Miyata (Автор), Yuta Haruna (Автор), Koyo Matsumura (Автор), Hideyuki Ogino (Автор), Serena Hirano (Автор), Kazuhiro Higashiyama (Автор), Mariko Takeda-Morishita (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2018-10-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Cell-penetrating peptides (CPPs) have great potential to efficiently deliver drug cargos across cell membranes without cytotoxicity. Cationic arginine and hydrophobic tryptophan have been reported to be key component amino acids for cellular internalization of CPPs. We recently found that l-arginine...