Recent progress in discovery of novel AAK1 inhibitors: from pain therapy to potential anti-viral agents

• Main Authors: Ying-Hui Yuan (Author), Nian-Dong Mao (Author), Ji-Long Duan (Author), Hang Zhang (Author), Carmen Garrido (Author), Frédéric Lirussi (Author), Yuan Gao (Author), Tian Xie (Author), Xiang-Yang Ye (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adaptor associated kinase 1 (AAK1), a member of the Ark1/Prk1 family of Ser/Thr kinases, is a specific key kinase regulating Thr156 phosphorylation at the μ2 subunit of the adapter complex-2 (AP-2) protein. Due to their important biological functions, AAK1 systems have been validated in clinics for...