AZD6738 Inhibits fibrotic response of conjunctival fibroblasts by regulating checkpoint kinase 1/P53 and PI3K/AKT pathways

• Hauptverfasser: Longxiang Huang (Verfasst von), Qin Ye (Verfasst von), Chunlin Lan (Verfasst von), Xiaohui Wang (Verfasst von), Yihua Zhu (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Trabeculectomy can effectively reduce intraocular pressure (IOP) in glaucoma patients, the long-term surgical failure is due to the excessive proliferation and fibrotic response of conjunctival fibroblasts which causes the subconjunctival scar and non-functional filtering bleb. In this study, we dem...