RNAi dynamics in Juvenile Fasciola spp. Liver flukes reveals the persistence of gene silencing in vitro.

• Main Authors: Paul McVeigh (Author), Erin M McCammick (Author), Paul McCusker (Author), Russell M Morphew (Author), Angela Mousley (Author), Abbas Abidi (Author), Khalid M Saifullah (Author), Raman Muthusamy (Author), Ravikumar Gopalakrishnan (Author), Terry W Spithill (Author), John P Dalton (Author), Peter M Brophy (Author), Nikki J Marks (Author), Aaron G Maule (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fasciola spp. liver fluke cause pernicious disease in humans and animals. Whilst current control is unsustainable due to anthelmintic resistance, gene silencing (RNA interference, RNAi) has the potential to contribute to functional validation of new therapeutic targets. The susceptibility of juvenil...