Dracorhodin Perchlorate Induces Apoptosis via Activation of Caspases and Generation of Reactive Oxygen Species

• Hoofdauteurs: Mingyu Xia (Auteur), Dong Wang (Auteur), Minwei Wang (Auteur), Shin-ichi Tashiro (Auteur), Satoshi Onodera (Auteur), Mutsuhiko Minami (Auteur), Takashi Ikejima (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2004-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Dracorhodin perchlorate inhibited proliferation of several tumor cell lines. The drug induced oligonucleosomal fragmentation of DNA in HeLa cells and increased caspase-3, -8, -9 activities followed by the degradation of caspase-3 substrates, inhibitor of caspase-dependent DNase, and poly-(ADP-ribose...