Dracorhodin Perchlorate Induces Apoptosis via Activation of Caspases and Generation of Reactive Oxygen Species

• Autori principali: Mingyu Xia (Autore), Dong Wang (Autore), Minwei Wang (Autore), Shin-ichi Tashiro (Autore), Satoshi Onodera (Autore), Mutsuhiko Minami (Autore), Takashi Ikejima (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2004-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Dracorhodin perchlorate inhibited proliferation of several tumor cell lines. The drug induced oligonucleosomal fragmentation of DNA in HeLa cells and increased caspase-3, -8, -9 activities followed by the degradation of caspase-3 substrates, inhibitor of caspase-dependent DNase, and poly-(ADP-ribose...