Pt(II)-PLGA Hybrid in a pH-Responsive Nanoparticle System Targeting Ovarian Cancer

• Egile Nagusiak: Marek T. Wlodarczyk (Egilea), Sylwia A. Dragulska (Egilea), Ying Chen (Egilea), Mina Poursharifi (Egilea), Maxier Acosta Santiago (Egilea), John A. Martignetti (Egilea), Aneta J. Mieszawska (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Platinum-based agents are the main treatment option in ovarian cancer (OC). Herein, we report a poly(lactic-co-glycolic acid) (PLGA) nanoparticle (NP) encapsulating platinum (II), which is targeted to a cell-spanning protein overexpressed in above 90% of late-stage OC, mucin 1 (MUC1). The NP is coat...