Pt(II)-PLGA Hybrid in a pH-Responsive Nanoparticle System Targeting Ovarian Cancer

• Main Authors: Marek T. Wlodarczyk (Author), Sylwia A. Dragulska (Author), Ying Chen (Author), Mina Poursharifi (Author), Maxier Acosta Santiago (Author), John A. Martignetti (Author), Aneta J. Mieszawska (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Platinum-based agents are the main treatment option in ovarian cancer (OC). Herein, we report a poly(lactic-co-glycolic acid) (PLGA) nanoparticle (NP) encapsulating platinum (II), which is targeted to a cell-spanning protein overexpressed in above 90% of late-stage OC, mucin 1 (MUC1). The NP is coat...