Pt(II)-PLGA Hybrid in a pH-Responsive Nanoparticle System Targeting Ovarian Cancer

• Prif Awduron: Marek T. Wlodarczyk (Awdur), Sylwia A. Dragulska (Awdur), Ying Chen (Awdur), Mina Poursharifi (Awdur), Maxier Acosta Santiago (Awdur), John A. Martignetti (Awdur), Aneta J. Mieszawska (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2023-02-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Platinum-based agents are the main treatment option in ovarian cancer (OC). Herein, we report a poly(lactic-co-glycolic acid) (PLGA) nanoparticle (NP) encapsulating platinum (II), which is targeted to a cell-spanning protein overexpressed in above 90% of late-stage OC, mucin 1 (MUC1). The NP is coat...