Polyenes in Medium Chain Length Polyhydroxyalkanoate (mcl-PHA) Biopolymer Microspheres with Reduced Toxicity and Improved Therapeutic Effect against <i>Candida</i> Infection in Zebrafish Model

• Main Authors: Aleksandar Pavic (Author), Zoran Stojanovic (Author), Marina Pekmezovic (Author), Đorđe Veljović (Author), Kevin O'Connor (Author), Ivana Malagurski (Author), Jasmina Nikodinovic-Runic (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immobilizing antifungal polyenes such as nystatin (Nys) and amphotericin B (AmB) into biodegradable formulations is advantageous compared to free drug administration providing sustained release, reduced dosing due to localized targeting and overall reduced systemic drug toxicity. In this study, we e...