Polyenes in Medium Chain Length Polyhydroxyalkanoate (mcl-PHA) Biopolymer Microspheres with Reduced Toxicity and Improved Therapeutic Effect against <i>Candida</i> Infection in Zebrafish Model

• Hauptverfasser: Aleksandar Pavic (Verfasst von), Zoran Stojanovic (Verfasst von), Marina Pekmezovic (Verfasst von), Đorđe Veljović (Verfasst von), Kevin O'Connor (Verfasst von), Ivana Malagurski (Verfasst von), Jasmina Nikodinovic-Runic (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2022-03-01T00:00:00Z.
• Schlagworte: article
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Immobilizing antifungal polyenes such as nystatin (Nys) and amphotericin B (AmB) into biodegradable formulations is advantageous compared to free drug administration providing sustained release, reduced dosing due to localized targeting and overall reduced systemic drug toxicity. In this study, we e...