Polyenes in Medium Chain Length Polyhydroxyalkanoate (mcl-PHA) Biopolymer Microspheres with Reduced Toxicity and Improved Therapeutic Effect against <i>Candida</i> Infection in Zebrafish Model

• Hoofdauteurs: Aleksandar Pavic (Auteur), Zoran Stojanovic (Auteur), Marina Pekmezovic (Auteur), Đorđe Veljović (Auteur), Kevin O'Connor (Auteur), Ivana Malagurski (Auteur), Jasmina Nikodinovic-Runic (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-03-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Immobilizing antifungal polyenes such as nystatin (Nys) and amphotericin B (AmB) into biodegradable formulations is advantageous compared to free drug administration providing sustained release, reduced dosing due to localized targeting and overall reduced systemic drug toxicity. In this study, we e...