G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1

• Päätekijät: Yi Sun (Tekijä), Ping Leng (Tekijä), Pengcheng Guo (Tekijä), Huanshen Gao (Tekijä), Yikai Liu (Tekijä), Chenkai Li (Tekijä), Zhenghui Li (Tekijä), Haining Zhang (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: BMC, 2021-08-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract Background Apoptosis of chondrocyte is involved in osteoarthritis (OA) pathogenesis, and mechanical stress plays a key role in this process by activation of Piezo1. However, the negative regulation of signal conduction mediated by mechanical stress is still unclear. Here, we elucidate that...