G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1

• Main Authors: Yi Sun (Author), Ping Leng (Author), Pengcheng Guo (Author), Huanshen Gao (Author), Yikai Liu (Author), Chenkai Li (Author), Zhenghui Li (Author), Haining Zhang (Author)
• Format: Knjiga
• Izdano: BMC, 2021-08-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract Background Apoptosis of chondrocyte is involved in osteoarthritis (OA) pathogenesis, and mechanical stress plays a key role in this process by activation of Piezo1. However, the negative regulation of signal conduction mediated by mechanical stress is still unclear. Here, we elucidate that...