Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors

• Asıl Yazarlar: Ningbo Qin (Yazar), Tatsunori Sasaki (Yazar), Wei Li (Yazar), Jian Wang (Yazar), Xiangyu Zhang (Yazar), Dahong Li (Yazar), Zhanlin Li (Yazar), Maosheng Cheng (Yazar), Huiming Hua (Yazar), Kazuo Koike (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Protein tyrosine phosphatase 1B (PTP1B) is an attractive molecular target for anti-diabetes, anti-obesity, and anti-cancer drug development. From the seeds of Silybum marianum, nine flavonolignans, namely, silybins A, B (1, 2), isosilybins A, B (3, 4), silychristins A, B (5, 6), isosilychristin A (7...