Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors

• Main Authors: Ningbo Qin (Author), Tatsunori Sasaki (Author), Wei Li (Author), Jian Wang (Author), Xiangyu Zhang (Author), Dahong Li (Author), Zhanlin Li (Author), Maosheng Cheng (Author), Huiming Hua (Author), Kazuo Koike (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protein tyrosine phosphatase 1B (PTP1B) is an attractive molecular target for anti-diabetes, anti-obesity, and anti-cancer drug development. From the seeds of Silybum marianum, nine flavonolignans, namely, silybins A, B (1, 2), isosilybins A, B (3, 4), silychristins A, B (5, 6), isosilychristin A (7...