Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors

• Автори: Ningbo Qin (Автор), Tatsunori Sasaki (Автор), Wei Li (Автор), Jian Wang (Автор), Xiangyu Zhang (Автор), Dahong Li (Автор), Zhanlin Li (Автор), Maosheng Cheng (Автор), Huiming Hua (Автор), Kazuo Koike (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Protein tyrosine phosphatase 1B (PTP1B) is an attractive molecular target for anti-diabetes, anti-obesity, and anti-cancer drug development. From the seeds of Silybum marianum, nine flavonolignans, namely, silybins A, B (1, 2), isosilybins A, B (3, 4), silychristins A, B (5, 6), isosilychristin A (7...