Novel N-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks

• Egile Nagusiak: John N. Philoppes (Egilea), Mohamed A. Abdelgawad (Egilea), Mohammed A. S. Abourehab (Egilea), Mohamed Sebak (Egilea), Mostafa A. Darwish (Egilea), Phoebe F. Lamie (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Three novel series of N-methylsulfonylindole derivatives 3a&b, 4a-e, and 5a-e were synthesised. Different biological activities of the synthesised compounds were studied. Antimicrobial activity showed that, compounds 4b, 4e and 5d had selective antibacterial activity against the Gram-negative ba...