Novel N-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks

• Hoofdauteurs: John N. Philoppes (Auteur), Mohamed A. Abdelgawad (Auteur), Mohammed A. S. Abourehab (Auteur), Mohamed Sebak (Auteur), Mostafa A. Darwish (Auteur), Phoebe F. Lamie (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Three novel series of N-methylsulfonylindole derivatives 3a&b, 4a-e, and 5a-e were synthesised. Different biological activities of the synthesised compounds were studied. Antimicrobial activity showed that, compounds 4b, 4e and 5d had selective antibacterial activity against the Gram-negative ba...