Novel N-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks

• Главные авторы: John N. Philoppes (Автор), Mohamed A. Abdelgawad (Автор), Mohammed A. S. Abourehab (Автор), Mohamed Sebak (Автор), Mostafa A. Darwish (Автор), Phoebe F. Lamie (Автор)
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• Опубликовано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предметы: article
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Three novel series of N-methylsulfonylindole derivatives 3a&b, 4a-e, and 5a-e were synthesised. Different biological activities of the synthesised compounds were studied. Antimicrobial activity showed that, compounds 4b, 4e and 5d had selective antibacterial activity against the Gram-negative ba...