Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis

• Main Authors: Mahmoud E. Youssef (Author), Eslam E. Abd El-Fattah (Author), Amir M. Abdelhamid (Author), Hanan Eissa (Author), Eman El-Ahwany (Author), Noha A. Amin (Author), Helal F. Hetta (Author), Mohamed H. Mahmoud (Author), Gaber El-Saber Batiha (Author), Naglaa Gobba (Author), Ahmed Gaafar Ahmed Gaafar (Author), Sameh Saber (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Empagliflozin and metformin are widely used for the treatment of type 2 diabetes. These drugs showed marked anti-inflammatory effects in different animal models via enhancing AMPK activity. Yet, the protective anti-inflammatory effects of their combination against ulcerative colitis have not been pr...