Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis

• প্রধান লেখক: Mahmoud E. Youssef (লেখক), Eslam E. Abd El-Fattah (লেখক), Amir M. Abdelhamid (লেখক), Hanan Eissa (লেখক), Eman El-Ahwany (লেখক), Noha A. Amin (লেখক), Helal F. Hetta (লেখক), Mohamed H. Mahmoud (লেখক), Gaber El-Saber Batiha (লেখক), Naglaa Gobba (লেখক), Ahmed Gaafar Ahmed Gaafar (লেখক), Sameh Saber (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Empagliflozin and metformin are widely used for the treatment of type 2 diabetes. These drugs showed marked anti-inflammatory effects in different animal models via enhancing AMPK activity. Yet, the protective anti-inflammatory effects of their combination against ulcerative colitis have not been pr...