Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis

• Hauptverfasser: Mahmoud E. Youssef (Verfasst von), Eslam E. Abd El-Fattah (Verfasst von), Amir M. Abdelhamid (Verfasst von), Hanan Eissa (Verfasst von), Eman El-Ahwany (Verfasst von), Noha A. Amin (Verfasst von), Helal F. Hetta (Verfasst von), Mohamed H. Mahmoud (Verfasst von), Gaber El-Saber Batiha (Verfasst von), Naglaa Gobba (Verfasst von), Ahmed Gaafar Ahmed Gaafar (Verfasst von), Sameh Saber (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Empagliflozin and metformin are widely used for the treatment of type 2 diabetes. These drugs showed marked anti-inflammatory effects in different animal models via enhancing AMPK activity. Yet, the protective anti-inflammatory effects of their combination against ulcerative colitis have not been pr...