The Dynamic Intestinal Absorption Model (Diamod®), an in vitro tool to study the interconnected kinetics of gastrointestinal solubility, supersaturation, precipitation, and intestinal permeation processes of oral drugs

• मुख्य लेखकों: Frédéric Moens (लेखक), Gies Vandevijver (लेखक), Anke De Blaiser (लेखक), Adam Larsson (लेखक), Fabio Spreafico (लेखक), Patrick Augustijns (लेखक), Massimo Marzorati (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

This study aimed at developing the Diamod® as a dynamic gastrointestinal transfer model with physically interconnected permeation. The Diamod® was validated by studying the impact of the intraluminal dilution of a cyclodextrin-based itraconazole solution and the negative food effect for indinavir su...