The Dynamic Intestinal Absorption Model (Diamod®), an in vitro tool to study the interconnected kinetics of gastrointestinal solubility, supersaturation, precipitation, and intestinal permeation processes of oral drugs

• 主要な著者: Frédéric Moens (著者), Gies Vandevijver (著者), Anke De Blaiser (著者), Adam Larsson (著者), Fabio Spreafico (著者), Patrick Augustijns (著者), Massimo Marzorati (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2023-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

This study aimed at developing the Diamod® as a dynamic gastrointestinal transfer model with physically interconnected permeation. The Diamod® was validated by studying the impact of the intraluminal dilution of a cyclodextrin-based itraconazole solution and the negative food effect for indinavir su...