LC-MS/MS Method for Measurement of Thiopurine Nucleotides (TN) in Erythrocytes and Association of TN Concentrations With TPMT Enzyme Activity

LC-MS/MS Method for Measurement of Thiopurine Nucleotides (TN) in Erythrocytes and Association of TN Concentrations With TPMT Enzyme Activity

Monitoring concentrations of thiopurine metabolites is used clinically to prevent adverse effects in patients on thiopurine drug therapy. We developed a LC-MS/MS method for the quantification of 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) in red blood cells (RBCs). This method utilizes a...

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Main Authors: Amol O. Bajaj (Author), Mark M. Kushnir (Author), Erik Kish-Trier (Author), Rachel N. Law (Author), Lauren M. Zuromski (Author), Alejandro R. Molinelli (Author), Gwendolyn A. McMillin (Author), Kamisha L. Johnson-Davis (Author)
Format: Book
Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
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