Comparison of High and Low Affinity Serotonin 1A Receptors by PET In Vivo in Nonhuman Primates

• मुख्य लेखकों: J.S. Dileep Kumar (लेखक), Matthew S. Milak (लेखक), Vattoly J. Majo (लेखक), Jaya Prabhakaran (लेखक), Pratap Mali (लेखक), Lyudmila Savenkova (लेखक), J. John Mann (लेखक), Ramin V. Parsey (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2012-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Serotonin (5-HT) 1A receptors exist in high and low affinity states. Agonist ligands bind preferentially to the high affinity state receptors, providing a more functionally relevant measure than antagonist binding. We now report comparison of 5-HT1A binding in vivo using both [11C]CUMI-101 (agonist)...